In vitro prediction of in vivo human intestinal absorbability

CACO tool is a drug discovery tool based on differentiated CACO2 cells monolayer grown on  transwell plates.
CACO2 is an immortalized cell line derived from a human epithelial colorectal adenocarcinoma. When cultured on 24 transwell plates, the cells differentiate into a polarized epithelial monolayer that forms a physical and biochemical barrier to the passage of ions and small molecules.
CACO tool provides polarized cultures of CACO2 cells on polycarbonate microporous filters. The cells are grown and differentiated upon customer request, up to 21 days.

Application

• Drug discovery platform
• Drugs absorption studies
• Transport inhibition studies
• In-vitro model of the human small intestinal mucosa

Features and benefits

Time saving: no need to develop your own test
Cost saving: early decision on promising compounds
Easy to use: user friendly assay, suitable for HTS

High quality: CACO tool is produced under ISO9001
Shipment: supported by solid phase medium

Services upon request

areta can perform in house the CACO tool assay, analyze the samples or deliver them to the customer for further investigation.

Download full slide